Neuropathic pain ( NP) is a kind of pain caused by lesions or diseases of the somatosensory nervous system，which can lead to motor，sensory，and autonomic dysfunction and seriously affect the quality of life of patients． In recent years，the incidence of NP is increasing，which seriously affects the quality of life of patients and brings a great burden to fam-ilies and society． Due to the unclear pathogenesis of NP，there is no specific treatment for this disease clinically． This review aims to provide some reference for the prevention and treatment of NP by summarizing the existing possible pathogenesis，diag-nosis and treatment measures．

he cerebral glymphatic system is the main pathway for the metabolic clearance of waste from brain tissue，which is related to a variety of neurodegenerative diseases． As a non-invasive imaging technique，the newly developed Diffu-sion tensor imaging analysis of perivascular space ( DTI-ALPS) has attracted more and more clinical attention as a non-invasive imaging technique that can evaluate the function of the human glymphatic system by quantifying the water diffusion rate along the perivascular channel． This article reviews the application progress and mechanism of DTI-ALPS in neurological diseases，and further puts forward the limitations of DTI-ALPS in the research of central nervous system diseases，so as to provide a new direction for the in-depth study of glymphatic neurological diseases．

Silicosis is a kind of occupational disease which is difficult to cure，has poor prognosis and high fatality rate． Systemic sclerosis is a chronic autoimmune disease characterized by autoantibody production，small vessel lesions，and fibroblast dysfunction，leading to uncontrolled deposition of extracellular matrix． Silicosis complicated with systemic sclerosis is clinically known as Erasmus syndrome，the pathogenesis of which has not yet been clarified，and no unified diagnosis and treatment norms have been formed． This article reviews relevant international and domestic studies on silicosis complicated with systemic sclerosis in recent years，providing reference for the diagnosis and treatment of silicosis complicated with systemic sclerosis．

Aplastic anemia ( AA) is a severe hematologic disorder characterized clinically by a reduction in all blood cell types and impairment of bone marrow hematopoiesis． Ｒomiplostim，as a Janus kinase inhibitor，has garnered widespread attention in recent years． This paper comprehensively and thoroughly discusses the mechanisms and clinical applications of romiplostim in the treatment of aplastic anemia from various perspectives． It explores the drug＇s mechanisms of action during the treatment process，its immunomodulatory effects，and potential side effects and safety considerations． Furthermore，the paper also outlines future research directions，particularly the development of personalized treatment strategies and the exploration of novel therapeutic targets，providing valuable insights and prospects for further advancements in the field．

Breast sarcoma is a rare breast disease，which is a group of malignant tumors originated from the mesenchymal tissue of the breast． Because of its unique medical history，treatment response and prognosis，it is necessary to develop different diagnostic methods and treatment strategies for this type of tumor． Because of its rarity，the current understanding of breast sarcoma is limited，mainly based on small retrospective studies or case reports． Therefore，the treatment generally refers to the conclusions drawn from randomized controlled trials of other soft tissue sarcomas． This article describes the etiology，diagnosis，treatment strategy and prognosis of breast sarcoma，and provides ideas for seeking new treatment methods．