Acute kidney injury(AKI) is one of the clinical diseases with the highest incidence rate in the world, characterized by rapid deterioration of renal function and further accumulation of metabolic wastes and toxins. Now more and more evidences show that necrotic apoptosis and ferroptosis are one of the main pathological mechanisms of AKI. This article reviews the definition, main biochemical mechanism, main regulatory factors and related research progress of necrotic apoptosis and Ferroptosis in AKI.

Sepsis is a common disease in intensive care units and a major cause of death for critically ill patients. Sepsis myocardial dysfunction is a common complication of sepsis caused by cardiac dysfunction. In this article, the following aspects were discussed: inflammatory reaction, myocardial inhibitor, mitochondrial function of myocardial cells, oxidative stress, calcium ion pump, Endoplasmic reticulum stress, myocardial cell apoptosis, cardiac microvascular function, Sympathetic nervous system and β Adrenergic receptor, complement and other aspects to elaborate the pathogenesis of myocardial dysfunction in sepsis, and explore the intervention role of autophagy in the above pathogenesis. Intervention of the pathophysiological process of sepsis myocardial dysfunction from the perspective of autophagy may become a new target for the treatment of the disease.